POST-TRANSPLANTATION MALIGNANT TUMORS AND THE CHALLENGES OF IMMUNOSUPPRESSIVE THERAPY IN TRANSPLANTED PATIENS DEVELOPING LYMPHOMA. MYCOPHENOLIC ACID – A POSSIBILITY. Doctoral theses
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Background: Long term use of immunosuppressive therapy in transplant recipients in order to prevent acute and chronic rejection increases the long term risk of cancer. This study evaluates the incidence of different organs’ cancer after renal transplantation and immunosuppressive therapy. Methods: This is a retrospective analysis of malignant tumors in renal graft recipients with more than...
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Several advances in the filed of organ transplantation in last decades have resulted in significant increase in the number and methods of transplantation. In this article various aspects of organ transplantation including immunosuppressive medications, common skin tumors seen in transplant recipients, possible mechanisms involved in increased incidence of skin tumors and finally preventive meas...
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IT IS KNOWN from animal studies 1 that malignant tumors may develop in certain conditions characterized by disturbances of the host's immune defenses. The same is apparently true in man. For example, patients suffering from agammaglobulinemia, hypogammaglobulinemia and deficiencies of cell mediated immunity have a high incidence of malignancy involving either lymphoid or other tissues.2,4 An in...
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Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examine...
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Background: Alterations of systemic metabolic parameters are always present vitamins in cancer in addition radiotherapy may increases and complicates these disorders. The analysis of each biochemical metabolic alterations may give more understanding to biochemistry of malignancy and improving the degree of radiotherapy. The current study aimed to follow up the changes of folate, vitamin B12 a...
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